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Proteintech antibodies casepase 8
Antibodies Casepase 8, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1090 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antibodies casepase 8 - by Bioz Stars, 2026-04

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IL-9 and Th9–associated markers are elevated in TS patients. A Representative IHC pictures showing PU.1, IRF4, and IL-9 expression in TS patients’ tracheal tissues. IL-9 staining was single-color IHC, CD4/IL-9 co-localization was not assessed. B Quantitative analysis of IHC-positive regions showing PU.1, IRF4, and IL-9 expression in TS tissues ( n = 3). C qRT-PCR analysis of TS tissues and blood samples ( n = 10) for cytokines and fibrosis markers. D , E WB analysis of TS tissues for IFN-γ, fibrosis indicators, IL-9, and IL-4. F ELISA data showing collagen levels in the blood of TS patients. To determine statistical significance, unpaired t-tests were used. In comparison to controls, * P < 0.05, ** P < 0.01; *** P < 0.001; **** P < 0.0001

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 and Th9–associated markers are elevated in TS patients. A Representative IHC pictures showing PU.1, IRF4, and IL-9 expression in TS patients’ tracheal tissues. IL-9 staining was single-color IHC, CD4/IL-9 co-localization was not assessed. B Quantitative analysis of IHC-positive regions showing PU.1, IRF4, and IL-9 expression in TS tissues ( n = 3). C qRT-PCR analysis of TS tissues and blood samples ( n = 10) for cytokines and fibrosis markers. D , E WB analysis of TS tissues for IFN-γ, fibrosis indicators, IL-9, and IL-4. F ELISA data showing collagen levels in the blood of TS patients. To determine statistical significance, unpaired t-tests were used. In comparison to controls, * P < 0.05, ** P < 0.01; *** P < 0.001; **** P < 0.0001

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Expressing, Staining, Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay, Comparison

Th1/Th2 cytokine balance is skewed in patients with TS. A Method for gating peripheral blood samples and BALF CD3 + CD4 + T cells. Representative FCM plots showing the populations of IL-9 + , IL-4 + , and IFN-γ + CD4 + T cells in the control and TS groups are shown in ( B , D , and F ). C , E , and G Quantitative evaluation of IL-9, IL-4, and IFN-γ expression in CD4 + T cells ( n = 10). Unpaired t -tests were used to determine statistical significance. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. controls. TS: traumatic tracheal stenosis; BALF: bronchoalveolar lavage fluid; FCM: flow cytometry

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: Th1/Th2 cytokine balance is skewed in patients with TS. A Method for gating peripheral blood samples and BALF CD3 + CD4 + T cells. Representative FCM plots showing the populations of IL-9 + , IL-4 + , and IFN-γ + CD4 + T cells in the control and TS groups are shown in ( B , D , and F ). C , E , and G Quantitative evaluation of IL-9, IL-4, and IFN-γ expression in CD4 + T cells ( n = 10). Unpaired t -tests were used to determine statistical significance. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. controls. TS: traumatic tracheal stenosis; BALF: bronchoalveolar lavage fluid; FCM: flow cytometry

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Control, Expressing, Flow Cytometry

IL-9 promotes fibroblast proliferation and activation via the TGF-β1 pathway in vitro. A Relative growth rate of HTFs treated with IL-9, IL-4 + TGF-β1, anti-IL-9, or SB at 24 h and 48 h, assessed by CCK-8 assay ( n = 5). B and C FCM histograms showing collagen I expression in CD3 − CD4 − HTFs following individual stimulation with IL-9, IL-4 + TGF-β1, anti-IL-9, or SB treatment. D and E ELISA and qRT-PCR analysis of collagen I secretion and COL1A1 mRNA expression in HTFs treated as above ( n = 5). F and G WB analysis of collagen III, collagen I, and α-SMA protein expression in HTFs following the same treatments ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. HTF: human tracheal fibroblast; SB: SB-431,542; FCM: flow cytometry; ELISA: enzyme-linked immunosorbent assay; qRT-PCR: quantitative real-time polymerase chain reaction; WB: western blot; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 promotes fibroblast proliferation and activation via the TGF-β1 pathway in vitro. A Relative growth rate of HTFs treated with IL-9, IL-4 + TGF-β1, anti-IL-9, or SB at 24 h and 48 h, assessed by CCK-8 assay ( n = 5). B and C FCM histograms showing collagen I expression in CD3 − CD4 − HTFs following individual stimulation with IL-9, IL-4 + TGF-β1, anti-IL-9, or SB treatment. D and E ELISA and qRT-PCR analysis of collagen I secretion and COL1A1 mRNA expression in HTFs treated as above ( n = 5). F and G WB analysis of collagen III, collagen I, and α-SMA protein expression in HTFs following the same treatments ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. HTF: human tracheal fibroblast; SB: SB-431,542; FCM: flow cytometry; ELISA: enzyme-linked immunosorbent assay; qRT-PCR: quantitative real-time polymerase chain reaction; WB: western blot; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Activation Assay, In Vitro, CCK-8 Assay, Expressing, Enzyme-linked Immunosorbent Assay, Quantitative RT-PCR, Control, Flow Cytometry, Real-time Polymerase Chain Reaction, Western Blot

IL-9 blockade suppresses TGF-β1-induced fibroblast activation and collagen I production in vitro. A FCM histograms depict collagen I expression in CD3 − CD4 − HTFs subjected to individually applied IL-9, IL-4, TGF-β1, anti-IL-9, anti-IL-4, anti-TGF-β1, IL-9 + TGF-β1, or anti-IL-9 + TGF-β1 treatment. B Quantitative FCM analysis of collagen I levels in CD3 − CD4 − HTFs treated as above ( n = 5). C – E qRT-PCR analysis of COL3A1, COL1A1, and α-SMA mRNA expression in HTFs treated with the aforementioned agents ( n = 5). F and G WB analysis of collagen III, collagen I, and α-SMA protein expression in HTFs treated as above ( n = 3). H and I IF analysis of α-SMA and collagen I expression in HTFs following treatment with the conditions described above ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. FCM: flow cytometry; qRT-PCR: quantitative real-time polymerase chain reaction; WB: western blot; IF: immunofluorescence; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 blockade suppresses TGF-β1-induced fibroblast activation and collagen I production in vitro. A FCM histograms depict collagen I expression in CD3 − CD4 − HTFs subjected to individually applied IL-9, IL-4, TGF-β1, anti-IL-9, anti-IL-4, anti-TGF-β1, IL-9 + TGF-β1, or anti-IL-9 + TGF-β1 treatment. B Quantitative FCM analysis of collagen I levels in CD3 − CD4 − HTFs treated as above ( n = 5). C – E qRT-PCR analysis of COL3A1, COL1A1, and α-SMA mRNA expression in HTFs treated with the aforementioned agents ( n = 5). F and G WB analysis of collagen III, collagen I, and α-SMA protein expression in HTFs treated as above ( n = 3). H and I IF analysis of α-SMA and collagen I expression in HTFs following treatment with the conditions described above ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. FCM: flow cytometry; qRT-PCR: quantitative real-time polymerase chain reaction; WB: western blot; IF: immunofluorescence; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Activation Assay, In Vitro, Expressing, Quantitative RT-PCR, Control, Flow Cytometry, Real-time Polymerase Chain Reaction, Western Blot, Immunofluorescence

IL-9 modulates Th1/Th2 cytokine profiles via TGF-β1 signaling in vitro . A , C , E , and G FCM scatter plots illustrate the distribution patterns of IL-9 + CD4 + , IL-4 + CD4 + , TGF-β1 + CD4 + , and IFN-γ + CD4 + T cell subsets across various treatment groups, including control, IL-9 alone, IL-4 + TGF-β1 co-stimulation, anti-IL-9 antibody alone, and SB alone. B , D , F , and H Quantification of FCM data for IL-9 + , IL-4 + , TGF-β1 + , and IFN-γ + CD4 + T cells in the treatment groups mentioned above ( n = 5). I and J ELISA and qRT-PCR analyses assessing protein and mRNA levels of IL-9, IL-4, IL-13, and IFN-γ following treatment with IL-9 or IL-4 + TGF-β1 co-stimulation, anti-IL-9 antibody, or SB ( n = 5). K and L WB analysis of IL-9, IL-4, IL-13, TGF-β1, and IFN-γ protein expression in the different treatment groups ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. FCM: flow cytometry; ELISA: enzyme-linked immunosorbent assay; qRT-PCR: quantitative real-time polymerase chain reaction; SB: SB-431,542; WB: western blot; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 modulates Th1/Th2 cytokine profiles via TGF-β1 signaling in vitro . A , C , E , and G FCM scatter plots illustrate the distribution patterns of IL-9 + CD4 + , IL-4 + CD4 + , TGF-β1 + CD4 + , and IFN-γ + CD4 + T cell subsets across various treatment groups, including control, IL-9 alone, IL-4 + TGF-β1 co-stimulation, anti-IL-9 antibody alone, and SB alone. B , D , F , and H Quantification of FCM data for IL-9 + , IL-4 + , TGF-β1 + , and IFN-γ + CD4 + T cells in the treatment groups mentioned above ( n = 5). I and J ELISA and qRT-PCR analyses assessing protein and mRNA levels of IL-9, IL-4, IL-13, and IFN-γ following treatment with IL-9 or IL-4 + TGF-β1 co-stimulation, anti-IL-9 antibody, or SB ( n = 5). K and L WB analysis of IL-9, IL-4, IL-13, TGF-β1, and IFN-γ protein expression in the different treatment groups ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. FCM: flow cytometry; ELISA: enzyme-linked immunosorbent assay; qRT-PCR: quantitative real-time polymerase chain reaction; SB: SB-431,542; WB: western blot; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: In Vitro, Control, Enzyme-linked Immunosorbent Assay, Quantitative RT-PCR, Expressing, Flow Cytometry, Real-time Polymerase Chain Reaction, Western Blot

Th9 blockers inhibit collagen secretion by fibroblasts via the TGF-β1/SMAD2/3 pathway. A Representative WB results display the levels of phosphorylated SMAD2/3 (p-SMAD2/3) and total SMAD2/3 proteins in samples from the control, IL-9, IL-4 + TGF-β1, anti-IL-9, and SB treatment groups. B Quantification of p-SMAD2/3 and SMAD2/3 protein expression following treatment as described in ( A ) ( n = 3). C Representative WB results show the levels of p-SMAD2/3 and SMAD2/3 proteins in samples from the control, IL-9, IL-4, TGF-β1, anti-IL-9, anti-IL-4, anti-TGF-β1, IL-9 + TGF-β1, and anti-IL-9 + TGF-β1 treatment groups. D and E Quantification of p-SMAD2/3 and SMAD2/3 protein expression following treatments as described in ( C ) ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. WB: western blot; SB: SB-431,542; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: Th9 blockers inhibit collagen secretion by fibroblasts via the TGF-β1/SMAD2/3 pathway. A Representative WB results display the levels of phosphorylated SMAD2/3 (p-SMAD2/3) and total SMAD2/3 proteins in samples from the control, IL-9, IL-4 + TGF-β1, anti-IL-9, and SB treatment groups. B Quantification of p-SMAD2/3 and SMAD2/3 protein expression following treatment as described in ( A ) ( n = 3). C Representative WB results show the levels of p-SMAD2/3 and SMAD2/3 proteins in samples from the control, IL-9, IL-4, TGF-β1, anti-IL-9, anti-IL-4, anti-TGF-β1, IL-9 + TGF-β1, and anti-IL-9 + TGF-β1 treatment groups. D and E Quantification of p-SMAD2/3 and SMAD2/3 protein expression following treatments as described in ( C ) ( n = 3). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. IL-9 group. WB: western blot; SB: SB-431,542; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Control, Expressing, Western Blot

IL-9 modulates the cytokine microenvironment in TS airways via the TGF-β1/SMAD2/3 pathway. A Tracheal tissues from the control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups were immunohistochemically stained with IL-9, IL-4, IL-13, TGF-β1, and IFN-γ. IL-9 staining was single-color IHC, CD4/IL-9 co-localization was not assessed. Scale bar = 200 μm ( n = 3 per group). B The observed expression patterns were confirmed by quantitative analysis of the cytokine-positive region (%). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. TS: traumatic tracheal stenosis; SB: SB-431,542; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 modulates the cytokine microenvironment in TS airways via the TGF-β1/SMAD2/3 pathway. A Tracheal tissues from the control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups were immunohistochemically stained with IL-9, IL-4, IL-13, TGF-β1, and IFN-γ. IL-9 staining was single-color IHC, CD4/IL-9 co-localization was not assessed. Scale bar = 200 μm ( n = 3 per group). B The observed expression patterns were confirmed by quantitative analysis of the cytokine-positive region (%). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. TS: traumatic tracheal stenosis; SB: SB-431,542; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Control, Staining, Expressing

IL-9 modulates IL-4, IFN-γ, and TGF-β1 in CD4 + T cells and reduces airway collagen I. A – F Representative FCM plots showing the percentages of CD3 − CD4 − collagen I + , IL-9 + , IL-4 + , IFN-γ + , and TGF-β1 + CD4 + T cells in various experimental groups ( n = 6). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. FCM: flow cytometry; SB: SB-431,542; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 modulates IL-4, IFN-γ, and TGF-β1 in CD4 + T cells and reduces airway collagen I. A – F Representative FCM plots showing the percentages of CD3 − CD4 − collagen I + , IL-9 + , IL-4 + , IFN-γ + , and TGF-β1 + CD4 + T cells in various experimental groups ( n = 6). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. FCM: flow cytometry; SB: SB-431,542; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Control, Flow Cytometry

IL-9 modulates the cytokine microenvironment in TS airways via the TGF-β1/SMAD2/3 pathway. A and B WB analysis was performed to examine the expression of fibrosis-related proteins, including collagen III, collagen I, phosphorylated SMAD2/3, total SMAD2/3, and α-SMA, as well as cytokines TGF-β1, IL-9, IL-4, IL-13, and IFN-γ, in tracheal tissues from control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups ( n = 3). C qRT-PCR (tissue and blood) was used to assess the mRNA expression levels of IL-9, IRF4, PU.1, IL-4, IL-13, IFN-γ, COL3A1, and COL1A1 in the same experimental groups ( n = 6). D ELISA (BALF and blood) was used to assess the protein expression levels of IL-9, IL-4, IL-13, and IFN-γ in the same experimental groups ( n = 6). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. TS: traumatic tracheal stenosis; WB: western blot; SB: SB-431,542; qRT-PCR: quantitative real-time polymerase chain reaction; ELISA: enzyme-linked immunosorbent assay; bronchoalveolar lavage fluid; ANOVA: analysis of variance

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: IL-9 modulates the cytokine microenvironment in TS airways via the TGF-β1/SMAD2/3 pathway. A and B WB analysis was performed to examine the expression of fibrosis-related proteins, including collagen III, collagen I, phosphorylated SMAD2/3, total SMAD2/3, and α-SMA, as well as cytokines TGF-β1, IL-9, IL-4, IL-13, and IFN-γ, in tracheal tissues from control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups ( n = 3). C qRT-PCR (tissue and blood) was used to assess the mRNA expression levels of IL-9, IRF4, PU.1, IL-4, IL-13, IFN-γ, COL3A1, and COL1A1 in the same experimental groups ( n = 6). D ELISA (BALF and blood) was used to assess the protein expression levels of IL-9, IL-4, IL-13, and IFN-γ in the same experimental groups ( n = 6). Statistical comparisons were performed using one-way ANOVA followed by Kruskal–Wallis or Newman–Keuls post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 vs. control group; # P < 0.05, ## P < 0.01, ### P < 0.001, and #### P < 0.0001 vs. TS group. TS: traumatic tracheal stenosis; WB: western blot; SB: SB-431,542; qRT-PCR: quantitative real-time polymerase chain reaction; ELISA: enzyme-linked immunosorbent assay; bronchoalveolar lavage fluid; ANOVA: analysis of variance

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Expressing, Control, Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay, Western Blot, Real-time Polymerase Chain Reaction

Proteomic analysis of tracheal tissue from rats in five groups (rat TS model). Heatmap showing the patterns of protein abundance that differ across the five experimental groups. A Control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups. B To identify important biological processes and functions, KEGG pathway and gene ontology enrichment analyses were conducted on differentially expressed proteins. C Grouped expression profiles showing patterns of grouped protein expression. TS: traumatic tracheal stenosis

Journal: Respiratory Research

Article Title: Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling

doi: 10.1186/s12931-025-03431-2

Figure Lengend Snippet: Proteomic analysis of tracheal tissue from rats in five groups (rat TS model). Heatmap showing the patterns of protein abundance that differ across the five experimental groups. A Control, TS, TS + IL-9, TS + anti-IL-9, and TS + SB groups. B To identify important biological processes and functions, KEGG pathway and gene ontology enrichment analyses were conducted on differentially expressed proteins. C Grouped expression profiles showing patterns of grouped protein expression. TS: traumatic tracheal stenosis

Article Snippet: IL-9 and anti-IL-9 were administered daily (MedChemExpress) [ – ], while SB was administered every other day [ ].

Techniques: Quantitative Proteomics, Control, Expressing

Journal: medRxiv

Article Title: Elevated Levels of IL-9 Fail to Suppress Pathogenic T helper 17 cells in Sjögren’s Disease

doi: 10.64898/2025.12.19.25335657

Figure Lengend Snippet:

Article Snippet: Over the course of six weeks, B6.NOD- Aec1Aec2 mice received an intraperitoneal (i.p.) injection of either an anti-IL-9 antibody (BE0181, BioXCell, Lebanon, NH) or an isotype antibody control (BE0085, BioXCell, Lebanon, NH) five times per week.

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